OPRPN
Chr 4opiorphin prepropeptide
Also known as: BPLP, PRL1, PROL1, opiorphin
The encoded protein (opiorphin) is an endogenous inhibitor of neprilysin and aminopeptidase N that prevents the breakdown of enkephalins and substance P, thereby modulating pain sensitivity through opioid-dependent pathways. No established Mendelian diseases are currently associated with mutations in this gene. The gene shows moderate tolerance to loss-of-function variants (pLI 0.39, LOEUF 1.73), suggesting haploinsufficiency is unlikely to cause severe developmental phenotypes.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
OPRPN · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools