OPN1MW3

Chr X

opsin 1, medium wave sensitive 3

Also known as: GCP, GOP

NCBI Gene: 101060233 ENSG00000269433 UniProt: P0DN78

The OPN1MW3 protein is a G protein-coupled photoreceptor in cone cells that responds to medium-wavelength (green) light by activating G proteins and decreasing intracellular cAMP levels to mediate green light perception. Mutations cause color vision defects affecting green light perception, with X-linked inheritance. This gene primarily affects the visual system without typically causing neurological manifestations in pediatric patients.

ResearchSummary from RefSeq, UniProt

Enables identical protein binding activity and photoreceptor activity. Involved in absorption of visible light; positive regulation of cytokinesis; and visual perception. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

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Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Exome coverage (gnomAD): 0 of 6 coding exons well covered in gnomAD exomes; exons 1, 2, 3, 4, 5, 6 poorly covered. Genomes: 0 of 6 (exons 1, 2, 3, 4, 5, 6 below).? see exons ↓