OPCML

Chr 11

opioid binding protein/cell adhesion molecule like

Also known as: IGLON1, OBCAM, OPCM

NCBI Gene: 4978 ENSG00000183715 UniProt: Q14982

The protein encoded by this gene is a GPI-anchored cell adhesion molecule that binds opioids in the presence of acidic lipids and exhibits selectivity for mu opioid ligands. Mutations in OPCML are associated with somatic ovarian cancer. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.575), suggesting some intolerance to complete protein loss.

ResearchSummary from RefSeq, OMIM, UniProt

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtOvarian cancer

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.57

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

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