OPCML
Chr 11opioid binding protein/cell adhesion molecule like
Also known as: IGLON1, OBCAM, OPCM
The protein encoded by this gene is a GPI-anchored cell adhesion molecule that binds opioids in the presence of acidic lipids and exhibits selectivity for mu opioid ligands. Mutations in OPCML are associated with somatic ovarian cancer. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.575), suggesting some intolerance to complete protein loss.
Primary Disease Associations & Inheritance
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
OPCML · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools