Ensembl is currently experiencing issues
The Ensembl REST API is temporarily unavailable. Some gene data (transcript details, protein domains) may be incomplete. Other data sources are unaffected.
You can check Ensembl's status at status.ensembl.org
OPA10
Chr 6ARreticulon 4 interacting protein 1
Also known as: NIMP, OPA10, Yim1
The protein is localized to mitochondria and interacts with reticulon 4, which inhibits neurite growth following spinal cord injury. Mutations cause optic atrophy 10 with or without ataxia, intellectual disability, and seizures through autosomal recessive inheritance. This condition affects both the visual system and can involve broader neurological manifestations including movement and cognitive impairments.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/OPA10?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
OPA10 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools