OOSP3

Chr 11

oocyte secreted protein family member 3

NCBI Gene: 112577461 ENSG00000285231 UniProt: A0A2R8YFM6 OMIM: 621112

Predicted to act upstream of or within blastocyst development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jun 2026]

OMIM Research

Predicted to act upstream of or within blastocyst development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in OOSP3?

gnomAD v4 · ~123k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 270

122 rare PASS variants

Rare truncating (LoF)

1 in 1,800

18 rare PASS variants

Rare synonymous (reference)

1 in 830

36 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for OOSP3. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~79k	1 in 300	1 in 2,400
African / African American	~21k	1 in 260	1 in 2,700
East Asian	~11k	1 in 210	none seen
European (Finnish)	~10k	1 in 1,500	none seen
Remaining (unassigned)	~8,185	1 in 180	≈ 1 in 1,600
Admixed American	~7,652	1 in 150	≈ 1 in 3,700
Ashkenazi Jewish	~4,618	≈ 1 in 2,300	none seen
South Asian	~2,417	≈ 1 in 510	≈ 1 in 1,500
Middle Eastern	~647	≈ 1 in 320	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 0 of 5 coding exons well covered in gnomAD exomes; exons 1, 2, 3, 4, 5 poorly covered. Genomes: all 5.? see exons ↓