OLMALINC

Chr 10

oligodendrocyte maturation-associated long intergenic non-coding RNA

Also known as: C10orf75, HI-LNC80, LINC00263, NCRNA00263, OLMALINCAS

NCBI Gene: 90271 ENSG00000235823 OMIM: 616240

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in OLMALINC?

gnomAD v4 · ~98k individuals · PASS only

Rare means allele frequency under

Rare missense

none observed

0 rare PASS variants

Rare truncating (LoF)

1 in 360

21 rare PASS variants

Rare synonymous (reference)

none observed

0 rare PASS variants

Rare missense and truncating variants are carried at similar rates in OLMALINC; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 7 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~63k	none seen	1 in 720
African / African American	~21k	none seen	1 in 1,500
East Asian	~8,972	none seen	1 in 1,300
European (Finnish)	~7,660	none seen	≈ 1 in 1,800
Admixed American	~7,647	none seen	1 in 780
Remaining (unassigned)	~6,670	none seen	1 in 360
South Asian	~2,418	none seen	≈ 1 in 2,400

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.