OIT3

Chr 10

oncoprotein induced transcript 3

Also known as: LZP

NCBI Gene: 170392ENSG00000138315UniProt: Q8WWZ8OMIM: 609330

This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

OMIMResearchGenerating clinical summary…
0
Active trials
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Pubs (1 yr)
—
P/LP submissions
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P/LP missense
1.16
LOEUF
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Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.16LOEUF
pLI 0.000
Z-score 0.96
OE 0.79 (0.55–1.16)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.96Z-score
OE missense 0.85 (0.77–0.94)
291 obs / 341.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.79 (0.55–1.16)
0≤0.351.4
Missense OE?0.85 (0.77–0.94)
0≤0.61.4
Synonymous OE?0.92
0≤1.21.6
LoF obs/exp: 19 / 24.1Missense obs/exp: 291 / 341.1Syn Z: 0.79

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

OIT3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients