OGG1
Chr 38-oxoguanine DNA glycosylase
Also known as: HMMH, HOGG1, MUTM, OGH1
The protein is a DNA repair enzyme that excises 8-oxoguanine and other oxidative DNA lesions, with both glycosylase and lyase activities for removing mutagenic base damage. Mutations cause renal cell carcinoma (clear cell type), though this appears to be a somatic rather than germline condition. The gene is highly tolerant to loss-of-function variation (very low pLI score), suggesting that germline mutations may not typically cause severe developmental disorders.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
OGG1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools