OGFRL1

Chr 6

opioid growth factor receptor like 1

Also known as: dJ331H24.1

NCBI Gene: 79627ENSG00000119900UniProt: Q5TC84

Predicted to enable opioid growth factor receptor activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

GeneReviewsResearchGenerating clinical summary…
0
Active trials
4
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.75
LOEUF
Multiple*
Mechanism· predicted
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GeneReview available — OGFRL1
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.75LOEUF
pLI 0.004
Z-score 2.31
OE 0.40 (0.23–0.75)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.39Z-score
OE missense 0.73 (0.64–0.84)
159 obs / 216.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.40 (0.23–0.75)
0≤0.351.4
Missense OE?0.73 (0.64–0.84)
0≤0.61.4
Synonymous OE?0.96
0≤1.21.6
LoF obs/exp: 7 / 17.4Missense obs/exp: 159 / 216.7Syn Z: 0.30

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

OGFRL1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients