OBP2B

Chr 9

odorant binding protein 2B

Also known as: LCN14, OBPIIb

The protein binds and transports small hydrophobic volatile molecules and is involved in olfactory function and chemosensory behavior. Based on the extremely low pLI score (0.000013) and high LOEUF score (1.545), this gene appears highly tolerant to loss-of-function variants, suggesting mutations are unlikely to cause significant disease. No established clinical disorders have been definitively linked to OBP2B mutations.

OMIMResearchSummary from RefSeq, UniProt, Mechanism
DNmechanismLOEUF 1.54
Clinical SummaryOBP2B
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.54LOEUF
pLI 0.000
Z-score 0.37
OE 0.87 (0.511.54)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.25Z-score
OE missense 0.93 (0.791.10)
93 obs / 100.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.87 (0.511.54)
00.351.4
Missense OE0.93 (0.791.10)
00.61.4
Synonymous OE1.14
01.21.6
LoF obs/exp: 8 / 9.2Missense obs/exp: 93 / 100.0Syn Z: -0.76
DN
0.6938th %ile
GOF
0.5464th %ile
LOF
0.1993th %ile

The highest-scoring mechanism for this gene is dominant-negative.

DNprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

OBP2B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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