OBP2A
Chr 9odorant binding protein 2A
Also known as: LCN13, OBP, OBP2C, OBPIIa, hOBPIIa
The protein binds and transports small hydrophobic volatile molecules including aldehydes and fatty acids through nasal mucus to olfactory receptors. No disease associations have been established for mutations in this gene based on the provided information. The gene shows low constraint against loss-of-function variants (pLI near 0, LOEUF >1.5), suggesting haploinsufficiency is likely tolerated.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
OBP2A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools