NXF5
Chr Xnuclear RNA export factor 5
The protein is potentially involved in exporting mRNA from the nucleus to the cytoplasm and may participate in polarized transport and localization of mRNA in neurons. Most transcript variants of this gene are subject to nonsense-mediated decay and may not produce functional proteins in vivo. The gene shows very low constraint against loss-of-function variants, and no established human disease associations have been definitively linked to NXF5 mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NXF5 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools