NXF5

Chr X

nuclear RNA export factor 5

This gene is one member of a family of nuclear RNA export factor genes. Most transcript variants are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Sep 2022]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
P/LP submissions
P/LP missense
1.69
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.69LOEUF
pLI 0.000
Z-score -0.63
OE 1.17 (0.811.69)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.37Z-score
OE missense 1.09 (0.951.26)
141 obs / 129.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.17 (0.811.69)
00.351.4
Missense OE?1.09 (0.951.26)
00.61.4
Synonymous OE?1.21
01.21.6
LoF obs/exp: 19 / 16.3Missense obs/exp: 141 / 129.0Syn Z: -1.16

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

NXF5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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