NXF2B
Chr Xnuclear RNA export factor 2B
Also known as: bA353J17.1
The protein facilitates the export of mRNA from the nucleus to the cytoplasm as part of the nuclear RNA export machinery. Mutations cause intellectual disability and developmental delay with X-linked inheritance. The gene shows significant constraint against loss-of-function variants, suggesting intolerance to reduced protein function.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NXF2B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools