NUTM2G
Chr 9NUT family member 2G
Also known as: FAM22G, NUTMG
The NUTM2G protein is a nuclear testis midline carcinoma family member involved in transcriptional regulation. Mutations cause autosomal recessive developmental and epileptic encephalopathy with severe intellectual disability, seizures, and brain malformations including microcephaly and cerebellar hypoplasia. The gene shows low constraint against loss-of-function variants, consistent with its recessive inheritance pattern.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NUTM2G · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools