NUTM2F

Chr 9

NUT family member 2F

Also known as: FAM22F, NUTMF

I notice that while you've provided the gene name NUTM2F and its constraint metrics (pLI and LOEUF scores), you haven't included the essential clinical information needed to write a summary according to your specifications. To write the 2-3 sentence clinical summary you've requested, I would need information about: - The protein's specific function - Associated diseases/phenotypes from mutations - Inheritance pattern - Mechanism of pathogenicity Could you please provide the clinical data for NUTM2F so I can write an appropriate summary for your pediatric neurogenetics portal?

LOEUF 1.22
Clinical SummaryNUTM2F
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.22LOEUF
pLI 0.000
Z-score 0.83
OE 0.79 (0.531.22)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-0.41Z-score
OE missense 1.06 (0.971.15)
406 obs / 383.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE0.79 (0.531.22)
00.351.4
Missense OE1.06 (0.971.15)
00.61.4
Synonymous OE0.95
01.21.6
LoF obs/exp: 15 / 18.9Missense obs/exp: 406 / 383.5Syn Z: 0.52

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

NUTM2F · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found