NUTM2B

Chr 10

NUT family member 2B

Also known as: FAM22B, bA119F19.1

NCBI Gene: 729262ENSG00000188199UniProt: A6NNL0

GeneReviewsResearchGenerating clinical summary…
0
Active trials
16
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.47
LOEUF
—
Mechanism
📖
GeneReview available — NUTM2B
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.47LOEUF
pLI 0.020
Z-score 0.86
OE 0.59 (0.27–1.47)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.89Z-score
OE missense 0.81 (0.70–0.93)
133 obs / 165.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.59 (0.27–1.47)
0≤0.351.4
Missense OE?0.81 (0.70–0.93)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 3 / 5.1Missense obs/exp: 133 / 165.1Syn Z: 0.20

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

NUTM2B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients