NTNG2

Chr 9

netrin G2

Also known as: LHLL9381, Lmnt2, NEDBASH, NTNG1, NetrinG2, bA479K20.1

NCBI Gene: 84628 ENSG00000196358 UniProt: Q96CW9

The netrin-G2 protein controls neuronal circuit formation and promotes neurite outgrowth of both axons and dendrites. Autosomal recessive mutations cause a neurodevelopmental disorder characterized by behavioral abnormalities, absent speech, and hypotonia. This gene is highly constrained against loss-of-function variants (pLI 0.999, LOEUF 0.201), indicating that biallelic mutations are likely to have significant developmental consequences.

ResearchSummary from RefSeq, OMIM, UniProt

Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in several processes, including regulation of cell projection organization; regulation of neuron migration; and synaptic membrane adhesion. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtNeurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia

Clinical highlights

Interpreting a novel variant

Loss of function is the curated mechanism (Gene2Phenotype) and the gene is intolerant of it in the population — truncating, frameshift and canonical splice variants carry more prior weight here than missense.Curated gene-level mechanism — a prior for triage, not a per-variant call.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.20

LOEUF· LoF intol.

LOF

Mechanism· G2P

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429