NTMT2

Chr 1

N-terminal Xaa-Pro-Lys N-methyltransferase 2

Also known as: C1orf184, HOMT1B, METTL11B, NTM1B

Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal protein amino acid methylation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.11
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.11LOEUF
pLI 0.004
Z-score 1.34
OE 0.53 (0.281.11)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.64Z-score
OE missense 0.85 (0.740.99)
127 obs / 149.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.53 (0.281.11)
00.351.4
Missense OE?0.85 (0.740.99)
00.61.4
Synonymous OE?0.71
01.21.6
LoF obs/exp: 5 / 9.4Missense obs/exp: 127 / 149.1Syn Z: 1.71

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

NTMT2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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