NTF3

Chr 12

neurotrophin 3

Also known as: HDNF, NGF-2, NGF2, NT-3, NT3

NCBI Gene: 4908ENSG00000185652UniProt: P20783

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
12
Active trials
24
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.37
LOEUF
LOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
LoF intolerant — likely haploinsufficient
LoF Constraint?
0.37LOEUF
pLI 0.932
Z-score 3.08
OE 0.08 (0.03–0.37)
Highly constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
1.74Z-score
OE missense 0.63 (0.54–0.74)
108 obs / 172.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.08 (0.03–0.37)
0≤0.351.4
Missense OE?0.63 (0.54–0.74)
0≤0.61.4
Synonymous OE?0.94
0≤1.21.6
LoF obs/exp: 1 / 13.0Missense obs/exp: 108 / 172.1Syn Z: 0.42

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

NTF3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Fibromyalgia (FM)tDCSDuloxetine

Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM)

RECRUITING
NCT07203339Phase NAHospital de Clinicas de Porto AlegreStarted 2025-09-30
Transcranial direct current stimulation (tDCS) plus placebo.Duloxetine (60 mg) once dailyHome-based transcranial direct current stimulation
Epilepsy

Precision Medicine in the Treatment of Epilepsy

RECRUITING
NCT05450822Gitte Moos KnudsenStarted 2022-02-18
LevetiracetamLevetiracetam TabletsLamotrigine tablet
Multiple Sclerosis

Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

NOT YET RECRUITING
NCT07475377Phase NAUniversity of Alabama at BirminghamStarted 2026-08-01
Time Restricted EatingUnrestricted eating
Menopausal SyndromeCognitive DeclineObesity & Overweight

Algal Lutein Against Decline of Intellectual Nimbleness

NOT YET RECRUITING
NCT07600567Phase NAPoznan University of Life SciencesStarted 2026-05-01
LuteinPlacebo
MigraineMigraine HeadacheMigraine Headache, With or Without Aura

The Impact of Acupuncture on Biomarkers of Brain Injury and Inflammatory Response in Migraine

ACTIVE NOT RECRUITING
NCT07292506Phase NAUniversity Medical Centre LjubljanaStarted 2025-11-03
Standard acupunctureElectroacupunctureLaser Acupuncture
Aromatic L-amino Acid Decarboxylase Deficiency

A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Severe AADC Deficiency

ACTIVE NOT RECRUITING
NCT06432140Phase PHASE2, PHASE3Shanghai Vitalgen BioPharma Co., Ltd.Started 2024-07-02
VGN-R09b injection
Healthy Adult Participants

Multilevel Exercise Response in Rowers

NOT YET RECRUITING
NCT07613619Poznan University of Physical EducationStarted 2026-05-17
2000-m rowing ergometer test6000-m rowing ergometer test
Relapsing Remitting Multiple Sclerosis (RRMS)

Indole-3-PROpionic Acid Clinical Trials - Multiple Sclerosis

RECRUITING
NCT07318129Phase NAGlostrup University Hospital, CopenhagenStarted 2026-01-26
PlaceboIndole-3-propionic acid (IPA)
Multiple System Atrophy

GDNF Gene Therapy for Multiple System Atrophy

ACTIVE NOT RECRUITING
NCT04680065Phase PHASE1Brain Neurotherapy Bio, Inc.Started 2023-10-03
AAV2-GDNF gene therapySham (Placebo) Surgery
Late-Life Depression

Effects of Specific Amino Acid Supplementation and Lifestyle Factors on Brain Ageing

RECRUITING
NCT07497347Phase NAIRCCS Centro San Giovanni di Dio FatebenefratelliStarted 2026-03-01
L-serine supplementationPlacebo
Preterm BirthMother-Infant InteractionInfant Development

Continuous Delivery Room Skin-to-skin-study for Moderate and Late Preterm Infants

RECRUITING
NCT05975203Phase NAUniversity of CologneStarted 2023-08-04
skin-to-skin contact
StrokeRehabilitationRehabilitation Outcome

Stroke Rehabilitation Through Intensive Exercise

NOT YET RECRUITING
NCT07650500Phase NAThe Swedish School of Sport and Health SciencesStarted 2026-08-01
LE-mCIMT-EXELE- mCIMT-TAU

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients