NRN1
Chr 6neuritin 1
Also known as: NRN, dJ380B8.2
The protein promotes neurite outgrowth and branching of neuritic processes in hippocampal and cortical neurons, functioning as a GPI-anchored protein that responds to neural activity and neurotrophins. The gene is highly constrained against loss-of-function variants (pLI = 0.86, LOEUF = 0.46), suggesting that mutations would likely cause significant neurological phenotypes, though specific associated diseases have not yet been definitively established in humans. Further research is needed to characterize the clinical manifestations of NRN1-related disorders.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NRN1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools