NR4A3
Chr 9nuclear receptor subfamily 4 group A member 3
The protein is a transcriptional activator that binds to specific DNA sequences to regulate gene expression controlling cell proliferation, survival, differentiation, metabolism, and inflammation across multiple tissue types. Mutations cause extraskeletal myxoid chondrosarcoma as a somatic cancer. This gene is highly constrained against loss-of-function mutations (pLI 0.91, LOEUF 0.36), suggesting intolerance to complete protein loss.
Some data sources returned errors (1)
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NR4A3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools