NPY2R
Chr 4neuropeptide Y receptor Y2
Also known as: NPY2-R
Enables G-protein alpha-subunit binding activity and peptide YY receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cardiac left ventricle morphogenesis; and outflow tract morphogenesis. Located in cilium and plasma membrane. Implicated in several diseases, including Huntington's disease; alcohol dependence; cocaine dependence; nicotine dependence; and obesity (multiple). Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Jun 2026]
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NPY2R · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
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Links to major genomics databases and tools