NPFFR1

Chr 10

neuropeptide FF receptor 1

Also known as: GPR147, NPFF1, NPFF1R1, OT7T022

NCBI Gene: 64106ENSG00000148734UniProt: Q9GZQ6OMIM: 607448

Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Located in cilium. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.92
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.92LOEUF
pLI 0.000
Z-score -1.57
OE 1.49 (1.01–1.92)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.48Z-score
OE missense 0.75 (0.67–0.84)
202 obs / 270.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.49 (1.01–1.92)
0≤0.351.4
Missense OE?0.75 (0.67–0.84)
0≤0.61.4
Synonymous OE?0.81
0≤1.21.6
LoF obs/exp: 18 / 12.1Missense obs/exp: 202 / 270.4Syn Z: 1.62

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

NPFFR1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients