NPBWR2

Chr 20

neuropeptides B and W receptor 2

Also known as: GPR8

NCBI Gene: 2832 ENSG00000125522 UniProt: P48146

The encoded protein is a G protein-coupled receptor that binds neuropeptides B and W and interacts with opioid ligands, functioning in neuroendocrine regulation and food intake control. The gene is extremely intolerant to loss-of-function variants (pLI near 1.0), but no established human disease has been definitively linked to NPBWR2 mutations in current medical literature. This receptor is expressed primarily in the frontal cortex and belongs to the same structural family as opioid and somatostatin receptors.

ResearchSummary from RefSeq, UniProt

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.78

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)