NOMO3
Chr 16NODAL modulator 3
Also known as: Nomo
NOMO3 encodes a component of the multi-pass translocon complex that mediates insertion of multi-pass membrane proteins into cellular membranes, working alongside the SEC61 complex during protein insertion. The gene is not well-established as a cause of human disease, with loss-of-function variants appearing to be well-tolerated based on population constraint metrics. NOMO3 is part of a highly duplicated gene family on chromosome 16, which may provide functional redundancy.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NOMO3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools