NOMO2
Chr 16NODAL modulator 2
The protein functions as a component of the multi-pass translocon complex that mediates insertion of multi-pass membrane proteins into cellular membranes. NOMO2 mutations cause neurodevelopmental disorders with intellectual disability, developmental delay, and seizures, typically presenting in infancy or early childhood. The condition follows an autosomal recessive inheritance pattern.
Some data sources returned errors (1)
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NOMO2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools