NOL9
Chr 1nucleolar protein 9
Also known as: Grc3, NET6
LOEUF 0.55
Clinical Summary— NOL9
⚡
Population Constraint (gnomAD)
Constrained for loss-of-function variants (OE-LoF 0.31) despite low pLI — interpret in context.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?
0.55LOEUF
pLI 0.009
Z-score 3.40
OE 0.31 (0.19–0.55)
More LoF-intolerant than ~75% of genes
Missense Constraint?
1.55Z-score
OE missense 0.77 (0.70–0.85)
283 obs / 366.3 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.31 (0.19–0.55)
0≤0.351.4
Missense OE?0.77 (0.70–0.85)
0≤0.61.4
Synonymous OE?1.08
0≤1.21.6
LoF obs/exp: 9 / 28.6Missense obs/exp: 283 / 366.3Syn Z: -0.71
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NOL9 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools