NME1-NME2
Chr 17NME1-NME2 readthrough
Also known as: NM23-LV, NMELV
The NME1-NME2 read-through transcript produces a protein of unknown function, and the clinical significance of this naturally occurring transcription between the neighboring NME1 and NME2 genes has not been determined. No specific diseases have been associated with mutations in this read-through transcript.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
26 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 10 | 0 | 10 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 1 | 5 | 0 | 0 | 6 |
Likely Benign | 1 | 1 | 0 | 1 | 3 |
Benign | 0 | 0 | 4 | 0 | 4 |
| Total | 2 | 6 | 15 | 1 | 24 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
NME1-NME2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools