NGF

Chr 1

nerve growth factor

Also known as: Beta-NGF, HSAN5, NGFB

NCBI Gene: 4803ENSG00000134259UniProt: P01138

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

GeneReviewsResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtNeuropathy, hereditary sensory and autonomic, 5

Clinical highlights

Gene-disease validity (ClinGen)
hereditary sensory and autonomic neuropathy · ARStrongappropriate for clinical testing
Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
12
Active trials
929
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.53
LOEUF
LOF
Mechanism· predicted
📖
GeneReview available — NGF
Authoritative clinical overview · Recommended first read
Open GeneReview ↗
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.53LOEUF
pLI 0.820
Z-score 2.21
OE 0.00 (0.00–0.53)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
0.90Z-score
OE missense 0.80 (0.69–0.93)
127 obs / 159.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.00 (0.00–0.53)
0≤0.351.4
Missense OE?0.80 (0.69–0.93)
0≤0.61.4
Synonymous OE?1.17
0≤1.21.6
LoF obs/exp: 0 / 5.7Missense obs/exp: 127 / 159.1Syn Z: -1.06

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

NGF · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
RETT Syndrome With Proven MECP2 Mutation

Repurposing Mirtazapine in Rett Syndrome

RECRUITING
NCT07430046Phase PHASE2University of TriesteStarted 2025-07-09
mirtazapine
RETT Syndrome With Proven MECP2 MutationRett Syndrome

Efficacy and Safety of NTI164 in Children and Young Adults With Rett Syndrome

NOT YET RECRUITING
NCT07257978Phase PHASE2, PHASE3Fenix Innovation GroupStarted 2027-07-01
NTI164Placebo
Fibromyalgia (FM)tDCSDuloxetine

Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM)

RECRUITING
NCT07203339Phase NAHospital de Clinicas de Porto AlegreStarted 2025-09-30
Transcranial direct current stimulation (tDCS) plus placebo.Duloxetine (60 mg) once dailyHome-based transcranial direct current stimulation
Epilepsy

Precision Medicine in the Treatment of Epilepsy

RECRUITING
NCT05450822Gitte Moos KnudsenStarted 2022-02-18
LevetiracetamLevetiracetam TabletsLamotrigine tablet
Multiple Sclerosis

Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

NOT YET RECRUITING
NCT07475377Phase NAUniversity of Alabama at BirminghamStarted 2026-08-01
Time Restricted EatingUnrestricted eating
Menopausal SyndromeCognitive DeclineObesity & Overweight

Algal Lutein Against Decline of Intellectual Nimbleness

NOT YET RECRUITING
NCT07600567Phase NAPoznan University of Life SciencesStarted 2026-05-01
LuteinPlacebo
MigraineMigraine HeadacheMigraine Headache, With or Without Aura

The Impact of Acupuncture on Biomarkers of Brain Injury and Inflammatory Response in Migraine

ACTIVE NOT RECRUITING
NCT07292506Phase NAUniversity Medical Centre LjubljanaStarted 2025-11-03
Standard acupunctureElectroacupunctureLaser Acupuncture
Aromatic L-amino Acid Decarboxylase Deficiency

A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Severe AADC Deficiency

ACTIVE NOT RECRUITING
NCT06432140Phase PHASE2, PHASE3Shanghai Vitalgen BioPharma Co., Ltd.Started 2024-07-02
VGN-R09b injection
Multiple Myeloma

Daratumumab-bortezomib-dexamethasone (Dara-VCd) vs Bortezomib-Thalidomide-Dexamethasone (VTd), Then Maintenance With Ixazomib (IXA) or IXA-Dara

ACTIVE NOT RECRUITING
NCT03896737Phase PHASE2European Myeloma Network B.V.Started 2019-04-16
Daratumumab plus Velcade Cyclophosphamide DexamethasoneVelcade Thalidomide Dexamethasone
Healthy Adult Participants

Multilevel Exercise Response in Rowers

NOT YET RECRUITING
NCT07613619Poznan University of Physical EducationStarted 2026-05-17
2000-m rowing ergometer test6000-m rowing ergometer test
Relapsing Remitting Multiple Sclerosis (RRMS)

Indole-3-PROpionic Acid Clinical Trials - Multiple Sclerosis

RECRUITING
NCT07318129Phase NAGlostrup University Hospital, CopenhagenStarted 2026-01-26
PlaceboIndole-3-propionic acid (IPA)
Multiple System Atrophy

GDNF Gene Therapy for Multiple System Atrophy

ACTIVE NOT RECRUITING
NCT04680065Phase PHASE1Brain Neurotherapy Bio, Inc.Started 2023-10-03
AAV2-GDNF gene therapySham (Placebo) Surgery

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients