NFX1
Chr 9nuclear transcription factor, X-box binding 1
NFX1 encodes a transcriptional repressor that binds to X-box motifs in MHC class II gene promoters to regulate their expression and limit the duration of inflammatory responses induced by interferon-gamma. The gene is highly constrained against loss-of-function variants (LOEUF 0.457), but pathogenic variants and associated human disease phenotypes have not been definitively established in the literature. Additional research is needed to determine the clinical significance of NFX1 variants in pediatric patients.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NFX1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools