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NEM2

Chr 2AR

nemaline myopathy 2, autosomal recessive

Nebulin is a giant actin-binding protein that regulates thin filament length and contractility in skeletal muscle. Mutations cause nemaline myopathy 2, a congenital myopathy characterized by muscle weakness and the presence of nemaline (rod-like) bodies in muscle fibers. This condition follows autosomal recessive inheritance.

GeneReviewsOMIMResearchSummary from OMIM
LOFmechanismAR1 OMIM phenotype
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GeneReview available — NEM2
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/NEM2?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

NEM2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC