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NEDSVH

Chr 1AD

chaperonin containing TCP1 subunit 3

Also known as: CCT-gamma, CCTG, NEDSVH, PIG48, TCP-1-gamma, TRIC5

The protein encoded by NEDSVH is a molecular chaperone within the CCT/TRiC complex that folds cytoskeletal proteins including actin and tubulin in an ATP-dependent manner. Mutations cause neurodevelopmental disorder with speech or visual impairment and brain hypomyelination with autosomal dominant inheritance. This condition affects multiple systems including cognition, communication, vision, and white matter development.

OMIMResearchSummary from RefSeq, OMIM
AD1 OMIM phenotype
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/NEDSVH?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

NEDSVH · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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No publications found for NEDSVH