Ensembl is currently experiencing issues
The Ensembl REST API is temporarily unavailable. Some gene data (transcript details, protein domains) may be incomplete. Other data sources are unaffected.
You can check Ensembl's status at status.ensembl.org
NEDDFAC
Chr 14ADSPT16 homolog, facilitates chromatin remodeling subunit
Also known as: CDC68, FACTP140, NEDDFAC, SPT16, SPT16/CDC68
NEDDFAC encodes the 140 kDa subunit of FACT (facilitates chromatin transcription), which interacts with histones H2A/H2B to facilitate nucleosome disassembly and transcription elongation through chromatin. Mutations cause autosomal dominant neurodevelopmental disorder with dysmorphic facies and thin corpus callosum, affecting both brain development and craniofacial morphology.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/NEDDFAC?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NEDDFAC · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools