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NEDBAVC

Chr 12AR

DEAH-box helicase 37

Also known as: DDX37, Dhr1, NEDBAVC, SRXY11

This gene encodes a DEAD box RNA helicase involved in RNA processing including translation initiation, splicing, and ribosome assembly. Biallelic mutations cause a neurodevelopmental disorder with brain anomalies and variable vertebral or cardiac anomalies, inherited in an autosomal recessive pattern. The condition affects multiple organ systems during development, reflecting the fundamental role of RNA helicases in cellular processes.

OMIMResearchSummary from RefSeq, OMIM
AR1 OMIM phenotype
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/NEDBAVC?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

NEDBAVC · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found