NEAT1

Chr 11

nuclear paraspeckle assembly transcript 1

Also known as: LINC00084, NCRNA00084, TP53LC15, TncRNA, VINC

NCBI Gene: 283131ENSG00000245532

This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

13
ClinVar variants
9
Pathogenic / LP
—
pLI score
1
Active trials
Clinical Summary— NEAT1
📋
ClinVar Variants
9 Pathogenic / Likely Pathogenic· 4 VUS of 13 total submissions
💊
Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

13 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic7
Likely Pathogenic2
VUS4
7
Pathogenic
2
Likely Pathogenic
4
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————7
Likely Pathogenic
————2
VUS
————4
Likely Benign
————0
Benign
————0
Total—13

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

NEAT1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease.
Shen Q et al.·J Adv Res
2021Review
Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
Zhang Y et al.·Cell Death Differ
2022
The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5.
Zhang M et al.·J Hematol Oncol
2018
N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer.
Wang J et al.·Cancer Commun (Lond)
2024
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty.
Luo OJ et al.·Nat Aging
2022
Human herpesvirus-associated transposable element activation in human aging brains with Alzheimer's disease.
Feng Y et al.·Alzheimers Dement
2025
Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer.
Jia Y et al.·J Exp Clin Cancer Res
2022
Combinatorial strategies targeting NEAT1 and AURKA as new potential therapeutic options for multiple myeloma.
Puccio N et al.·Haematologica
2024
Therapeutic prospects of ceRNAs in COVID-19.
Liu L et al.·Front Cell Infect Microbiol
2022Review
Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis.
Li C et al.·Mol Neurodegener
2023
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Electroacupuncture reduces neuroinflammation and neuronal pyroptosis via downregulating Neat1 in rats after stroke.
Lin W et al.·Stroke Vasc Neurol
2026
NEAT1 drives SARS-CoV-2 N protein-induced inflammation, metabolic reprogramming, and mitochondria-ER stress crosstalk.
Qing C et al.·Sci Rep
2026
Evaluation of serum NEAT1 and MALAT1 expression as diagnostic biomarkers in tyrosinemia, a rare metabolic disorder.
Motazedian N et al.·Orphanet J Rare Dis
2026
The Impact of NEAT1 on Inflammatory Responses and Processes in Arthropathic Diseases: Latest Findings and Perspectives.
Mohammad SI et al.·Biochem Genet
2026
The Oncogenic Role of Long Non-Coding RNA NEAT1 in Head and Neck Squamous Cell Carcinoma: From Molecular Mechanisms to Clinical Implications.
Shi Y et al.·Biology (Basel)
2026🔓 Open AccessFunctional
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Inflammatory Bowel Disease (IBD)

Diagnosis of Inflammatory Bowel Disease

NOT YET RECRUITING
NCT07400211Assiut UniversityStarted 2026-04-01

External Resources

Links to major genomics databases and tools