NDST4

Chr 4

N-deacetylase and N-sulfotransferase 4

Also known as: N-HSST, N-HSST 4, NDST-4, NHSST4

NCBI Gene: 64579ENSG00000138653UniProt: Q9H3R1OMIM: 615039

Predicted to enable deacetylase activity and heparan sulfate N-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.64
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.64LOEUF
pLI 0.000
Z-score 3.50
OE 0.44 (0.31–0.64)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.09Z-score
OE missense 0.85 (0.79–0.93)
380 obs / 444.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.44 (0.31–0.64)
0≤0.351.4
Missense OE?0.85 (0.79–0.93)
0≤0.61.4
Synonymous OE?1.07
0≤1.21.6
LoF obs/exp: 20 / 45.4Missense obs/exp: 380 / 444.7Syn Z: -0.69

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

NDST4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients