NDN

Necdin functions as a growth suppressor that facilitates cell cycle arrest in postmitotic neurons and acts as a transcription factor that binds to guanosine-rich DNA sequences. Mutations cause Prader-Willi syndrome, a complex neurodevelopmental disorder with neonatal hypotonia, feeding difficulties, hyperphagia, intellectual disability, and behavioral problems. The gene shows paternal-only expression due to genomic imprinting, so disease occurs through paternal deletions or maternal uniparental disomy of the 15q11-q13 region.