NCAPG

Chr 4

non-SMC condensin I complex subunit G

Also known as: CAPG, CHCG, NY-MEL-3, YCG1

NCBI Gene: 64151ENSG00000109805UniProt: Q9BPX3OMIM: 606280

This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

OMIMResearchGenerating clinical summary…
0
Active trials
55
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.61
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.61LOEUF
pLI 0.000
Z-score 3.69
OE 0.41 (0.29–0.61)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.10Z-score
OE missense 0.86 (0.80–0.93)
427 obs / 495.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.41 (0.29–0.61)
0≤0.351.4
Missense OE?0.86 (0.80–0.93)
0≤0.61.4
Synonymous OE?0.85
0≤1.21.6
LoF obs/exp: 19 / 46.0Missense obs/exp: 427 / 495.9Syn Z: 1.56

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

NCAPG · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients