NCAPD3
Chr 11ARnon-SMC condensin II complex subunit D3
Also known as: CAP-D3, CAPD3, MCPH22, hCAP-D3, hHCP-6, hcp-6
NCAPD3 encodes a regulatory subunit of the condensin-2 complex that establishes mitotic chromosome architecture and is essential for chromosome condensation and decatenation during cell division, particularly in neuronal stem cells during early neurogenesis. Mutations cause primary microcephaly 22, an autosomal recessive disorder affecting brain development and cortex size. The gene is highly constrained against loss-of-function variants (LOEUF 0.489), reflecting its essential role in normal neurodevelopment.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NCAPD3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools