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NBIA2B
Chr 22ARphospholipase A2 group VI
Also known as: CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14
The protein is an A2 phospholipase that catalyzes the release of fatty acids from phospholipids and is involved in phospholipid remodeling, arachidonic acid release, and leukotriene and prostaglandin synthesis. Mutations cause neurodegeneration with brain iron accumulation 2B, which follows autosomal recessive inheritance. This condition primarily affects the central nervous system with characteristic iron deposition in the brain.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/NBIA2B?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
NBIA2B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
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External Resources
Links to major genomics databases and tools