NAA11

Chr 4

N-alpha-acetyltransferase 11, NatA catalytic subunit

Also known as: ARD1B, ARD2, hARD2

NCBI Gene: 84779ENSG00000156269UniProt: Q9BSU3OMIM: 619432

Enables protein-N-terminal amino-acid acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Located in cytosol and nucleoplasm. Part of NatA complex. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.23
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.23LOEUF
pLI 0.010
Z-score 1.17
OE 0.54 (0.26–1.23)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.24Z-score
OE missense 0.94 (0.82–1.09)
135 obs / 142.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.54 (0.26–1.23)
0≤0.351.4
Missense OE?0.94 (0.82–1.09)
0≤0.61.4
Synonymous OE?0.94
0≤1.21.6
LoF obs/exp: 4 / 7.4Missense obs/exp: 135 / 142.9Syn Z: 0.35

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

NAA11 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients