MYO16

Chr 13

myosin XVI

Also known as: MYAP3, MYR8, Myo16b, NYAP3, PPP1R107

NCBI Gene: 23026ENSG00000041515UniProt: Q9Y6X6OMIM: 615479

This gene encodes an unconventional myosin that functions as an actin-based motor protein with ATPase activity and may target protein phosphatase 1 during brain development while regulating neuronal morphogenesis. The gene is highly constrained against loss-of-function variants (pLI ~1.0, LOEUF 0.27), and variants have been associated with susceptibility to schizophrenia. Inheritance pattern and specific pediatric phenotypes associated with pathogenic variants in this gene are not well established in the current literature.

OMIMResearchSummary from RefSeq, UniProt
LOEUF 0.27
Clinical Summary— MYO16
⚡
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 1.00). One damaged copy is likely sufficient to cause disease.
Explore recent and relevant literature in Research Assistant →

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
LoF intolerant — likely haploinsufficient
LoF Constraint
0.27LOEUF
pLI 0.999
Z-score 7.20
OE 0.18 (0.12–0.27)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint
1.03Z-score
OE missense 0.91 (0.86–0.96)
917 obs / 1008.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.18 (0.12–0.27)
0≤0.351.4
Missense OE0.91 (0.86–0.96)
0≤0.61.4
Synonymous OE1.01
0≤1.21.6
LoF obs/exp: 16 / 89.5Missense obs/exp: 917 / 1008.7Syn Z: -0.14

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MYO16 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Genome-Wide Association Study Candidate Genes on Mammary System-Related Teat-Shape Conformation Traits in Chinese Holstein Cattle
Nazar M et al.·Genes (Basel)
2021
The C-terminal tail extension of myosin 16 acts as a molten globule, including intrinsically disordered regions, and interacts with the N-terminal ankyrin
Telek E et al.·J Biol Chem
2021
Integrative genome-wide association study and transcriptomic analysis to identify candidate genes and pathways for heterophil and lymphocyte traits in white-feathered broilers
Zheng J et al.·Poult Sci
2026
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis
Menon S et al.·Mol Biol Cell
2021
Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.
Suetsugu H et al.·Hum Mol Genet
2022
Top 5 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
LncRNA MYO16-AS1 and MICAL2 axis sustains proliferation and migration in ovarian cancer cells and unveils a therapeutic vulnerability in patient-derived tumor organoids.
Ahmad M et al.·Noncoding RNA Res
2025Open Access
Disrupting of IGF2BP3-stabilized HK2 mRNA by MYO16-AS1 competitively binding impairs LUAD migration and invasion.
Li P et al.·Mol Cell Biochem
2024Open Access
A Competing Endogenous RNA Network and an 8-lncRNA Prognostic Signature Identify MYO16-AS1 as an Oncogenic lncRNA in Bladder Cancer.
Shen D et al.·DNA Cell Biol
2021
Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
Liu YF et al.·PLoS One
2015Open Access
Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia.
Rodriguez-Murillo L et al.·Neuropsychopharmacology
2014
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients