MYO16
Chr 13myosin XVI
Also known as: MYAP3, MYR8, Myo16b, NYAP3, PPP1R107
This gene encodes an unconventional myosin that functions as an actin-based motor protein with ATPase activity and may target protein phosphatase 1 during brain development while regulating neuronal morphogenesis. The gene is highly constrained against loss-of-function variants (pLI ~1.0, LOEUF 0.27), and variants have been associated with susceptibility to schizophrenia. Inheritance pattern and specific pediatric phenotypes associated with pathogenic variants in this gene are not well established in the current literature.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
500 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 78 | 0 | 78 |
Likely Pathogenic | 0 | 1 | 0 | 0 | 1 |
VUS | 1 | 294 | 15 | 0 | 310 |
Likely Benign | 1 | 21 | 4 | 23 | 49 |
Benign | 0 | 14 | 8 | 23 | 45 |
Conflicting | — | 6 | |||
| Total | 2 | 330 | 105 | 46 | 489 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
MYO16 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools