MYG1

Chr 12

MYG1 exonuclease

Also known as: C12orf10, Gamm1, MST024, MSTP024, MYG

NCBI Gene: 60314ENSG00000139637UniProt: Q9HB07

Enables 3'-5'-RNA exonuclease activity. Involved in mRNA processing; mitochondrial RNA metabolic process; and rRNA processing. Located in mitochondrion and nucleus. Is active in mitochondrial matrix; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
4
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.18
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.18LOEUF
pLI 0.000
Z-score 0.93
OE 0.78 (0.54–1.18)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.28Z-score
OE missense 1.05 (0.95–1.17)
237 obs / 225.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.78 (0.54–1.18)
0≤0.351.4
Missense OE?1.05 (0.95–1.17)
0≤0.61.4
Synonymous OE?0.98
0≤1.21.6
LoF obs/exp: 17 / 21.7Missense obs/exp: 237 / 225.3Syn Z: 0.15

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MYG1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients