MYCNOS

Chr 2

MYCN opposite strand

Also known as: MYCN-AS1, N-CYM, NCYM, NYCM

NCBI Gene: 10408ENSG00000233718UniProt: P40205

This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016]

133
ClinVar variants
47
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— MYCNOS
📋
ClinVar Variants
47 Pathogenic / Likely Pathogenic· 46 VUS of 133 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

133 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic38
Likely Pathogenic9
VUS46
Likely Benign26
Benign3
Conflicting6
38
Pathogenic
9
Likely Pathogenic
46
VUS
26
Likely Benign
3
Benign
6
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
6
0
32
0
38
Likely Pathogenic
5
2
2
0
9
VUS
2
37
6
1
46
Likely Benign
1
2
2
21
26
Benign
0
0
1
2
3
Conflicting
—6
Total14414324128

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

MYCNOS · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Super-enhancer MYCNOS-SE promotes chemoresistance in small cell lung cancer by recruiting transcription factors CTCF and KLF15.
Niu Y et al.·Oncogene
2025
Silencing of the Long Noncoding RNA MYCNOS1 Suppresses Activity of MYCN-Amplified Retinoblastoma Without RB1 Mutation.
Saengwimol D et al.·Invest Ophthalmol Vis Sci
2020
CTCF cooperates with noncoding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression.
Zhao X et al.·Oncogene
2016
De novo evolved gene product NCYM in the pathogenesis and clinical outcome of human neuroblastomas and other cancers.
Suenaga Y et al.·Jpn J Clin Oncol
2020Review
Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells.
Eberherr C et al.·Int J Oncol
2019
Identification of a lncRNA‑associated competing endogenous RNA‑regulated network in clear cell renal cell carcinoma.
Liu B et al.·Mol Med Rep
2019
The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells.
O'Brien EM et al.·BMC Cancer
2018
Vessel adherent growth represents a major challenge in the surgical resection of neuroblastoma and Is associated with adverse outcome.
Mühling J et al.·J Pediatr Surg
2019
Features of Feingold syndrome 1 dominate in subjects with 2p deletions including MYCN.
Burnside RD et al.·Am J Med Genet A
2018Case report
Constitutional 560.49 kb chromosome 2p24.3 duplication including the MYCN gene identified by SNP chromosome microarray analysis in a child with multiple congenital anomalies and bilateral Wilms tumor.
Micale MA et al.·Eur J Med Genet
2016Case report
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools