MVP-DT

Chr 16

MVP divergent transcript

I cannot provide a clinical summary for MVP-DT as no information about this gene's protein function, associated diseases, or inheritance pattern has been provided in the data below the rules. Without specific details about what the protein does, what conditions result from mutations, and how it is inherited, I cannot write an accurate clinical summary that adheres to the requirement of using only the information provided.

Research

ResearchGenerating clinical summary…

Clinical Summary— MVP-DT

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ClinVar Variants

159 unique Pathogenic / Likely Pathogenic· 374 VUS of 809 total submissions

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Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

809 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic116

Likely Pathogenic43

VUS374

Likely Benign199

Benign9

Conflicting53

116

Pathogenic

Likely Pathogenic

374

VUS

199

Likely Benign

Benign

Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	LoF	Missense + Inframe	Non-coding	Synonymous	Total
Pathogenic	106	8	2	0	116
Likely Pathogenic	27	15	1	0	43
VUS	12	354	5	3	374
Likely Benign	3	43	18	135	199
Benign	0	1	6	2	9
Conflicting	—				53
Total	148	421	32	140	794

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

130 pathogenic / likely-pathogenic (of 134) ClinVar copy-number / structural variants overlap MVP-DT — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →