MUCL3

Chr 6

mucin like 3

Also known as: C6orf37, DPCR1, PBLT

NCBI Gene: 135656ENSG00000168631UniProt: Q3MIW9

Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.72
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.72LOEUF
pLI 0.000
Z-score 2.71
OE 0.45 (0.29–0.72)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
2.36Z-score
OE missense 0.75 (0.70–0.81)
539 obs / 717.0 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.45 (0.29–0.72)
0≤0.351.4
Missense OE?0.75 (0.70–0.81)
0≤0.61.4
Synonymous OE?0.73
0≤1.21.6
LoF obs/exp: 13 / 28.6Missense obs/exp: 539 / 717.0Syn Z: 3.56

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MUCL3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients