MTUS2
Chr 13microtubule associated scaffold protein 2
Also known as: CAZIP, ICIS, KIAA0774, TIP150
This protein binds microtubules and regulates microtubule dynamics at their growing tips, potentially targeting the microtubule depolymerase KIF2C to microtubule plus-ends. The gene is highly constrained against loss-of-function variants (LOEUF 0.34), but no established human disease associations have been reported for MTUS2 mutations. Inheritance pattern cannot be determined without documented cases.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MTUS2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools