MT4

Chr 16

metallothionein 4

Also known as: MT-4, MT-IV, MTIV

NCBI Gene: 84560 ENSG00000102891 UniProt: P47944 OMIM: 606206

This protein binds zinc and copper ions and regulates zinc metabolism during epithelial cell differentiation. The gene is highly constrained against loss-of-function variants (pLI near 1, low LOEUF score), suggesting that mutations would likely cause severe developmental disorders. However, no specific disease associations have been established for this gene in the provided clinical data.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cellular response to zinc ion; detoxification of copper ion; and intracellular zinc ion homeostasis. Predicted to act upstream of or within intracellular monoatomic cation homeostasis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)