MT1G

Chr 16

metallothionein 1G

Also known as: MT1, MT1K

NCBI Gene: 4495ENSG00000125144UniProt: P13640

Enables zinc ion binding activity. Involved in several processes, including cellular response to cadmium ion; cellular response to copper ion; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
27
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.83
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.83LOEUF
pLI 0.032
Z-score 0.26
OE 0.82 (0.31–1.83)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.80Z-score
OE missense 1.38 (1.09–1.75)
48 obs / 34.7 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.82 (0.31–1.83)
0≤0.351.4
Missense OE?1.38 (1.09–1.75)
0≤0.61.4
Synonymous OE?1.06
0≤1.21.6
LoF obs/exp: 2 / 2.4Missense obs/exp: 48 / 34.7Syn Z: -0.19

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MT1G · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients