MT1F

Chr 16

metallothionein 1F

Also known as: MT1

NCBI Gene: 4494 ENSG00000198417 UniProt: P04733

The protein binds zinc and other heavy metals through cysteine-rich domains and is involved in cellular responses to metal ions like zinc and cadmium. Mutations cause neurodevelopmental disorders with intellectual disability and developmental delay, typically presenting in early childhood. The gene follows autosomal dominant inheritance and shows low constraint against loss-of-function variants.

ResearchSummary from RefSeq, UniProt

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.70

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)